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au:"Lacerda, Marcus VG"

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Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates
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Schappo, Ana Paula

; Bittencourt, Najara C

; Bertolla, Leticia P

; Forcellini, Sofia

; da Silva, Ana Beatriz Iung Enembreck

; dos Santos, Hellen Geremias

; Gervásio, João Henrique

; Lacerda, Marcus VG

; Lopes, Stefanie CP

; Costa, Fabio TM

; Albrecht, Letusa

Memórias do Instituto Oswaldo Cruz

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2021, Volume 116 elocation e210227

Resumo: En | Texto: En | PDF: En

BACKGROUND Plasmodium vivax, the major cause of malaria in Latin America, has a large subtelomeric multigene family called vir. In the P. vivax genome, about 20% of its sequences are vir genes. Vir antigens are grouped in subfamilies according to their sequence similarities and have been shown to have distinct roles and subcellular locations. However, little is known about vir subfamilies, especially when comes to their functions. OBJECTIVE To evaluate the diversity, antigenicity, and adhesiveness of Plasmodium vivax VIR-E. METHODS Vir-E genes were amplified from six P. vivax isolates from Manaus, North of Brazil. The presence of naturally acquired antibodies to recombinant PvBrVIR-E and PvAMA-1 was evaluated by ELISA. Binding capacity of recombinant PvBrVIR-E was assessed by adhesion assay to CHO-ICAM1 cells. FINDINGS Despite vir-E sequence diversity, among those identified sequences, a representative one was chosen to be expressed as recombinant protein. The presence of IgM or IgG antibodies to PvBrVIR-E was detected in 23.75% of the study population while the presence of IgG antibodies to PvAMA-1 antigen was 66.25% in the same population. PvBrVIR-E was adhesive to CHO-ICAM1. MAIN CONCLUSIONS PvBrVIR-E was antigenic and adhesive to CHO-ICAM1.

https://doi.org/10.1590/0074-02760210227

An overview of malaria transmission from the perspective of Amazon Anopheles vectors
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Pimenta, Paulo FP

; Orfano, Alessandra S

; Bahia, Ana C

; Duarte, Ana PM

; Ríos-Velásquez, Claudia M

; Melo, Fabrício F

; Pessoa, Felipe AC

; Oliveira, Giselle A

; Campos, Keillen MM

; Villegas, Luis Martínez

; Rodrigues, Nilton Barnabé

; Nacif-Pimenta, Rafael

; Simões, Rejane C

; Monteiro, Wuelton M

; Amino, Rogerio

; Traub-Cseko, Yara M

; Lima, José BP

; Barbosa, Maria GV

; Lacerda, Marcus VG

; Tadei, Wanderli P

; Secundino, Nágila FC

Memórias do Instituto Oswaldo Cruz

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Fev 2015, Volume 110 Nº 1 Páginas 23 - 47

Resumo: En | Texto: En | PDF: En

In the Americas, areas with a high risk of malaria transmission are mainly located in the Amazon Forest, which extends across nine countries. One keystone step to understanding the Plasmodium life cycle in Anopheles species from the Amazon Region is to obtain experimentally infected mosquito vectors. Several attempts to colonise Ano- pheles species have been conducted, but with only short-lived success or no success at all. In this review, we review the literature on malaria transmission from the perspective of its Amazon vectors. Currently, it is possible to develop experimental Plasmodium vivax infection of the colonised and field-captured vectors in laboratories located close to Amazonian endemic areas. We are also reviewing studies related to the immune response to P. vivax infection of Anopheles aquasalis, a coastal mosquito species. Finally, we discuss the importance of the modulation of Plasmodium infection by the vector microbiota and also consider the anopheline genomes. The establishment of experimental mosquito infections with Plasmodium falciparum, Plasmodium yoelii and Plasmodium berghei parasites that could provide interesting models for studying malaria in the Amazonian scenario is important. Understanding the molecular mechanisms involved in the development of the parasites in New World vectors is crucial in order to better determine the interaction process and vectorial competence.

https://doi.org/10.1590/0074-02760140266 9346 downloads

Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
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Lizcano, Omaira Vera

; Resende, Sarah Stela

; Chehuan, Yonne F

; Lacerda, Marcus VG

; Brito, Cristiana FA

; Zalis, Mariano G

Memórias do Instituto Oswaldo Cruz

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Nov 2014, Volume 109 Nº 7 Páginas 948 - 951

Resumo: En | Texto: En | PDF: En

The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.

https://doi.org/10.1590/0074-0276140241 1537 downloads

Influence of age on the haemoglobin concentration of malaria-infected patients in a reference centre in the Brazilian Amazon
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Siqueira, Andre M

; Cavalcante, Janieldo A

; Vítor-Silva, Shelia

; Reyes-Lecca, Roberto C

; Alencar, Aline C

; Monteiro, Wuelton M

; Alexandre, Márcia AA

; Maria Paula G, Mourão

; Guinovart, Caterina

; Bassat, Quique

; Alecrim, Maria das Graças C

; Lacerda, Marcus VG

Memórias do Instituto Oswaldo Cruz

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Ago 2014, Volume 109 Nº 5 Páginas 569 - 576

Resumo: En | Texto: En | PDF: En

Anaemia is amongst the major complications of malaria, a major public health problem in the Amazon Region in Latin America. We examined the haemoglobin (Hb) concentrations of malaria-infected patients and compared it to that of malaria-negative febrile patients and afebrile controls. The haematological parameters of febrile patients who had a thick-blood-smear performed at an infectious diseases reference centre of the Brazilian Amazon between December 2009-January 2012 were retrieved together with clinical data. An afebrile community control group was composed from a survey performed in a malaria-endemic area. Hb concentrations and anaemia prevalence were analysed according to clinical-epidemiological status and demographic characteristics. In total, 7,831 observations were included. Patients with Plasmodium falciparum infection had lower mean Hb concentrations (10.5 g/dL) followed by P. vivax-infected individuals (12.4 g/dL), community controls (12.8 g/dL) and malaria-negative febrile patients (13.1 g/dL) (p < 0.001). Age, gender and clinical-epidemiological status were strong independent predictors for both outcomes. Amongst malaria-infected individuals, women in the reproductive age had considerably lower Hb concentrations. In this moderate transmission intensity setting, both vivax and falciparum malaria are associated with reduced Hb concentrations and risk of anaemia throughout a wide age range.

https://doi.org/10.1590/0074-0276140132 9861 downloads

Slow clearance of Plasmodium vivax with chloroquine amongst children younger than six months of age in the Brazilian Amazon
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Siqueira, André M

; Coutinho, Lucas I

; Gurgel, Rafael L

; Su, Willian CS

; Carvalho, Luiz M

; Benzecry, Silvana G

; Alencar, Aline CC

; Alexandre, Márcia AA

; Alecrim, Maria Graças C

; Lacerda, Marcus VG

Memórias do Instituto Oswaldo Cruz

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Ago 2014, Volume 109 Nº 5 Páginas 540 - 545

Resumo: En | Texto: En | PDF: En

Plasmodium vivax is the most widespread parasite causing malaria, being especially prevalent in the Americas and Southeast Asia. Children are one of the most affected populations, especially in highly endemic areas. However, there are few studies evaluating the therapeutic response of infants with vivax malaria. This study retrospectively evaluated the parasitaemia clearance in children diagnosed with vivax malaria during the first five days of exclusive treatment with chloroquine (CQ). Infants aged less than six months old had a significantly slower parasitaemia clearance time compared to the group of infants and children between six months and 12 years old (Kaplan-Meier survival analysis; Wilcoxon test; p = 0.004). The impaired clearance of parasitaemia in younger children with vivax malaria is shown for the first time in Latin America. It is speculated that CQ pharmacokinetics in young children with vivax malaria is distinct, but this specific population may also allow the detection of CQ-resistant parasites during follow-up, due to the lack of previous immunity.

https://doi.org/10.1590/0074-0276130068 1290 downloads

Red blood cells derived from peripheral blood and bone marrow CD34+ human haematopoietic stem cells are permissive to Plasmodium parasites infection
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Fernandez-Becerra, Carmen

; Lelievre, Joel

; Ferrer, Mireia

; Anton, Nuria

; Thomson, Richard

; Peligero, Cristina

; Almela, Maria Jesus

; Lacerda, Marcus VG

; Herreros, Esperanza

; del Portillo, Hernando A

Memórias do Instituto Oswaldo Cruz

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Set 2013, Volume 108 Nº 6 Páginas 801 - 803

Resumo: En | Texto: En | PDF: En

The production of fully functional human red cells in vitro from haematopoietic stem cells (hHSCs) has been successfully achieved. Recently, the use of hHSCs from cord blood represented a major improvement to develop the continuous culture system for Plasmodium vivax. Here, we demonstrated that CD34+hHSCs from peripheral blood and bone marrow can be expanded and differentiated to reticulocytes using a novel stromal cell. Moreover, these reticulocytes and mature red blood cells express surface markers for entrance of malaria parasites contain adult haemoglobin and are also permissive to invasion by P. vivax and Plasmodium falciparum parasites.

https://doi.org/10.1590/0074-0276108062013019 2410 downloads

On cytoadhesion of Plasmodium vivax: raison d'être?
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Costa, Fabio TM

; Lopes, Stefanie CP

; Ferrer, Mireia

; Leite, Juliana A

; Martin-Jaular, Lorena

; Bernabeu, Maria

; Nogueira, Paulo A

; Mourão, Maria Paula G

; Fernandez-Becerra, Carmen

; Lacerda, Marcus VG

; Portillo, Hernando del

Memórias do Instituto Oswaldo Cruz

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Ago 2011, Volume 106 Supl. 1 Páginas 79 - 84

Resumo: En | Texto: En | PDF: En

It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.

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Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon
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Ramos Júnior, Wilson M

; Sardinha, José FJ

; Costa, Mônica RF

; Santana, Marli S

; Alecrim, Maria GC

; Lacerda, Marcus VG

Brazilian Journal of Infectious Diseases

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Ago 2010, Volume 14 Nº 4 Páginas 410 - 412

Resumo: En | Texto: En | PDF: En

This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.

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The role of platelet and plasma markers of antioxidant status and oxidative stress in thrombocytopenia among patients with vivax malaria
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Araujo, Claudio F

; Lacerda, Marcus VG

; Abdalla, Dulcineia SP

; Lima, Emerson S

Memórias do Instituto Oswaldo Cruz

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Set 2008, Volume 103 Nº 6 Páginas 517 - 521

Resumo: En | Texto: En | PDF: En

Malaria remains an important health problem in tropical countries like Brazil. Thrombocytopenia is the most common hematological disturbance seen in malarial infection. Oxidative stress (OS) has been implicated as a possible mediator of thrombocytopenia in patients with malaria. This study aimed to investigate the role of OS in the thrombocytopenia of Plasmodium vivax malaria through the measurement of oxidant and antioxidant biochemical markers in plasma and in isolated platelets. Eighty-six patients with P. vivax malaria were enrolled. Blood samples were analyzed for total antioxidant and oxidant status, albumin, total protein, uric acid, zinc, magnesium, bilirubin, total thiols, glutathione peroxidase (GPx), malondialdehyde (MDA), antibodies against mildly oxidized low-density lipoproteins (LDL-/nLDL ratio) and nitrite/nitrate levels in blood plasma and GPx and MDA in isolated platelets. Plasma MDA levels were higher in thrombocytopenic (TCP) (median 3.47; range 1.55-12.90 µmol/L) compared with the non-thrombocytopenic (NTCP) patients (median 2.57; range 1.95-8.60 µmol/L). Moreover, the LDL-/nLDL autoantibody ratio was lower in TCP (median 3.0; range 1.5-14.8) than in NTCP patients (median 4.0; range 1.9-35.5). Finally, GPx and MDA were higher in the platelets of TPC patients. These results suggest that oxidative damage of platelets might be important in the pathogenesis of thrombocytopenia found in P. vivax malaria as indicated by alterations of GPx and MDA.

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